Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.

SANTA CLARA — When Isaac Guerendo trots on to the field with the first team Sunday at Levi’s Stadium, he will equal the same ...

Kyle Shanahan explains why 49ers rookie Isaac Guerendo is ready to be the starter with Christian McCaffrey and Jordan Mason ...

During the regular season I update my Dynasty Fantasy Football rankings once per week. You can always find links to the ...

Isaac Guerendo will make his first NFL start on Sunday as the injury-depleted San Francisco 49ers face the Chicago Bears. The ...

Givens suffered a torn pec in the 49ers’ Week 13 loss to the Buffalo Bills. His injury-riddled season is over after only ...

Henry will be the only must-start member of this backfield when they return in Week 15 to face the Giants. James Cook (Week ...

The San Francisco 49ers are falling behind the Seattle Seahawks in the NFC West. Losers of three consecutive contests, it was ...

There are bad bye weeks, and then there are season-ruining bye weeks. This could be the latter for many teams needing a ...

Former Wisconsin Badgers running back Isaac Guerendo is in line to serve as the San Francisco 49ers starting running back for ...

The San Francisco 49ers are preparing for rookie running back Isaac Guerendo to take on the primary ball-carrying duties for ...

Rookie fourth-round pick Isaac Guerendo seemed to be an afterthought in the San Francisco 49ers backfield with Christian ...