Group I introns are small RNAs (250-500 nt) capable of catalyzing their own splicing from the precursor RNA. They are widely distributed across the tree of life and have intricate relationships with ...

What if you could flip a genetic switch to silence a gene, then turn it back on with a simple drug? For researchers, gene-switch tools offer that kind of control—and a new system called Cyclone may ...

i have an issue with a very crowded sashimi plot of a whole gene that is difficult to read: this gets even worse if a add a white background to text. i know i could just zoom into the event, but i ...

Hello, I'm wondering if there's a setting or if other people have this issue as well (searching I could not find it). When we map with STAR, most of our data looks great. However, a small number of ...

Oncologists share their treatment preferences for patients with advanced NSCLC with EGFR mutations. Improving survival and quality of life for patients with NSCLC is of the utmost importance in the ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

Aided by two molecular control factors, the spliceosome rejects pre-mRNA that could be incorrectly spliced. While GPATCH1 detects the defective pre-mRNA, DHX35 removes it from the spliceosome, which ...

1 The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China 2 School of Rehabilitation Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan ...

Construction of an O-GlcNAc responsive GFP biosensor. a. Schematic of the GFP reporter (left, drawn to scale) and predicted changes in reporter splicing and expression upon varying cellular O-GlcNAc ...

Groundbreaking research uncovers the role of miRNAs in driving cancer while offering innovative diagnostic tools and therapies, including solutions to chemotherapy resistance. Study: miRNA interplay: ...

If globular protein domains consist of smaller units, folding and evolution would be facilitated. The fact that natural eukaryotic proteins are genetically partitioned in exons suggests that these may ...