News-Medical.Net

Study provides a new paradigm for managing transplant‑related immune complications

Acute graft-versus-host disease (aGVHD) is one of the most serious complications after allogeneic hematopoietic stem cell ...
EurekAlert!

Activated CD8+ T cells enable early prediction and precision treatment of acute graft‑versus‑host disease

Acute graft-versus-host disease (aGVHD) is a life-threatening complication after allogeneic hematopoietic stem cell ...
Targeted Oncology

For a Second Time, FDA Denies Approval of Tab-Cel in EBV+ PTLD

In July 2025, a class 2 resubmission of tab-cel’s BLA was initiated by Atara Biotherapeutics, developer and sponsor of ...
Frontiers

The TCR and LCK: foundations for T-cell activation and therapeutic innovation

The T cell receptor (TCR)-CD3 complex is crucial to adaptive immunity, driving antigen recognition and intracellular signaling cascades. CD3 subunits harbor key cytoplasmic motifs that recruit ...
Johns Hopkins Medicine

Johns Hopkins Scientists Develop Targeted Therapy for T-Cell Lymphomas and Leukemias

New from @hopkinskimmel: Researchers developed a TRBC2-targeting antibody–drug conjugate that selectively kills T-cell cancers while sparing healthy T cells in mice and lab models. The work expands a ...
Frontiers

Human tolerogenic dendritic cell subtypes exert divergent effects on induction of cytotoxic CD4 + T cells

Autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS) are debilitating conditions, caused by a breach in immune tolerance to self-tissues and leading to uncontrolled and ...