Studies in normal cells have shown that forced expression of oncogenic H-Ras can induce a senescence-like permanent growth arrest (Serrano et al., 1997; Lin et al., 1998; Lin and Lowe, 2001).
Xiao Wen Mao, Nina C. Nishiyama, Mary Campbell-Beachler, Peter Gifford, Kristine E. Haynes, Daila S. Gridley and Michael J. Pecaut The purpose of this study was to determine whether nicotinamide ...