eLife

Translational reading frame determines the pathogenicity of C-terminal frameshift deletions in MeCP2: an alternative therapeutic approach

This study offers important insight into the pathogenic basis of intragenic frameshift deletions in the carboxy-terminal domain of MECP2, which account for some Rett syndrome cases, yet similar ...
Modern Engineering Marvels on MSN

GRIN2A null variants linked to childhood-onset mental disorders and L-serine therapy

Could one genetic mutation be sufficient to bring on complex psychopathology? For decades, dominant models of mental ...

ArriVent Announces First Patient Dosed in Global Pivotal Phase 3 ALPACCA Trial Evaluating Firmonertinib for First-Line Treatment of EGFR PACC Mutant Non-Small Cell Lung Cancer

Firmonertinib has the potential to redefine first-line treatment in this underserved population as a once daily, oral, brain-penetrant, ...
IEEE

A Dual Mutation-Based Evolutionary Algorithm for Dynamic Multiobjective Optimization With Undetectable Changes

Abstract: Most of the current research on dynamic multiobjective optimization problems (DMOPs) assumes that environmental changes can be detectable. However, undetectable changes are frequently ...
Health and Me on MSN

This one gene may be triggering mental illness in children; scientists say it changes everything

German scientists have identified rare GRIN2A gene variants that may directly cause early-onset mental illness, sometimes without epilepsy or intellectual disability. The study shows null mutations ...