Multidrug resistance (MDR) is a major cause of failure in cancer chemotherapy. It is commonly caused by efflux of anticancer drugs by ABC transporters including ABCG2. ABCG2 is also a cancer stem cell ...

Mild cognitive impairment (MCI) is characterized by a decline in cognitive functioning without significant interference in daily activities. Its high heterogeneity and elevated conversion rate to ...

Hirschsprung’s disease (HSCR) is characterized by congenital absence of ganglion cells in the gastrointestinal tract, which leads to impaired defecation, constipation and intestinal obstruction. The ...

Abstract: MicroRNAs (miRNAs) are reported to play essential roles in cancer initiation and progression and microarray technologies are intensively applied to study the miRNA expression profile in ...

Building on on the observation of an increase in miR-182-5p in diabetic patients, the authors investigated the role of miR-182-5p and its target gene LRP6 in dysregulated glucose tolerance and fatty ...

The rapid pace of studies on microRNA regulation and function necessitates the development of suitable techniques for measuring and modulating microRNAs in different model systems. This review ...

Background: We have shown that the late-pregnant (LP) rodent is more vulnerable to myocardial ischemia-reperfusion injury (IRI) compared to non-pregnant (NP). The molecular mechanisms are unknown.

Background: Cell-free microRNAs (miRNAs) exist in body fluid. Previous studies showed that cell-free mi-RNAs are partly bound in microvesicles, and could transfer between cells via fusion with cell ...