This contribution is part of the special series of Inaugural Articles by members of the National Academy of Sciences elected in 2014. Contributed by Shiv I. S. Grewal, November 10, 2015 (sent for ...

Heterochromatin, sometimes known as the “dark side of the genome,” is a poorly studied fraction of DNA that makes up about half of our genetic material. For more than 50 years scientists have puzzled ...

The new study reveals a remarkable way that cells keep us safe from transposable elements (TEs) gone wild. The researchers found that cells have taken advantage of an entire protein network to repress ...

Chromocenters are established after the 2-cell (2C) stage during mouse embryonic development, but the factors that mediate chromocenter formation remain largely unknown. To identify regulators of 2C ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Heterochromatin, a key component of the ...

A recent study In Press at the Journal of Cell Biology reports that herpes simplex virus 1 (HSV-1) exploits heterochromatin to successfully exit the nucleus. The heterochromatin markers macroH2A1 and ...

Department of Bioengineering, University of Illinois at Urbana−Champaign, 1102 Everitt Lab, 1406 W. Green Street, Urbana, Illinois 61801, United States Biomedical Research Center, Mills Breast Cancer ...

Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel ...

In response to DNA double-strand breaks (DSBs), chromatin modifications orchestrate DNA repair pathways thus safeguarding genome integrity. Recent studies have uncovered a key role for heterochromatin ...

A long-standing puzzle in evolution is why new genes — ones that seem to arise out of nowhere — can quickly take over functions essential for an organism’s survival. A new study in fruit flies may ...