The Lahey Clinic, Boston, Massachusetts. Sise, L. F. — Anesthetist, Lahey Clinic, and New England Baptist Hospital, Boston. Woodbridge, P. D. — Anesthetist, Lahey ...

A new synthetic strategy can catalytically access all carbene polarities with one mechanism. This mild and tuneable method reduces the complexity of forming certain cyclopropanes and offers ...

To increase the oral availability of certain therapeutic compounds, chemists will sometimes tack an ester group onto the molecule. These so-called prodrugs have a longer physiological lifetime, ...

Previously undescribed chemical process may offer safer, more practical way to create cyclopropanes—a key feature in many drugs and drug-candidates. Chemical structures called cyclopropanes can ...

Synthetic biologists have genetically tweaked soil bacteria to make compounds containing chains of three-membered rings that are so energy dense that they outmuscle advanced rocket fuel. Cyclopropanes ...

1 Institute of Drug Discovery Technology, Ningbo University, Ningbo, China 2 State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of ...

We report the development of an iron-based biocatalytic strategy for the asymmetric synthesis of fused cyclopropane-γ-lactams, which are key structural motifs found in synthetic drugs and bioactive ...