2 Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Isehara, Japan 3 Department of Anatomy & Neurobiology, Graduate School of Medicine, Osaka City ...

Altmetric provides a collated score for online attention across various platforms and media. See more details Cre-loxP technology, a cornerstone in fate mapping and in vivo gene function studies, ...

Background: The Cre/LoxP system is widely used in cardiovascular research to generate mouse models with tissue-specific inactivation of target genes. Studies have reported that expression of Cre ...

Mice and newts were applied to the one-step Cre-loxP organism creation technology by TAx9. In this study, the researchers succeeded in synthesizing a Cre-loxP integrated vector by placing a short DNA ...

Wt1-Cre-based tools are important reagents for studying epicardial cell fate and gene function. In contrast to recently reported results, we show that constitutive Wt1 GFPCre in combination with ...

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"One limitation [of Cre-LoxP], the focus of this editorial, is the potential loss of fidelity of Cre recombinase expression especially in the context of modeling cancer in mice." In this new editorial ...

A new editorial paper was published in Oncoscience (Volume 10) on November 14, 2023, entitled, "Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research." In this new ...

The development of tools to manipulate the mouse genome, including knockout and transgenic technology, has revolutionized our ability to explore gene function in mammals. Moreover, for genes that are ...

From the Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China (B.Z.); and the ...