San Francisco star running back Christian McCaffrey exited the 49ers Sunday Night Football game against the Bills with a knee ...

The 49ers star running back was ruled out of Sunday Night Football after suffering a knee injury in the first half against ...

Somehow Week 13 was worse than for the San Francisco 49ers than Week 12. The 49ers fell behind 21-3 at halftime and had a ...

QB Brock Purdy injured his shoulder in Week 11 against the Seattle Seahawks and wound up missing the team’s blowout Week 12 ...

San Francisco 49ers running back Christian McCaffrey is feared to have suffered a season-ending PCL injury vs. the Buffalo ...

San Francisco 49ers linebacker Fred Warner exited with cramps, but then later returned in the first half vs. the Buffalo ...

During Sunday Night Football against the Bills, Isaac Guerendo punched in his second touchdown of his rookie campaign.

San Francisco running back Christian McCaffrey was officially ruled out of the 49ers’ Sunday Night Football contest at the ...

The San Francisco 49ers are extremely banged up going into their Week 13 showdown with the Buffalo Bills. However, they will ...

Buffalo’s grounds crew has made an effort to clear the field. They had a tarp on that has now been removed, and they’ve ...

In the first half, defensive tackle Kevin Givens exited the game with a chest injury. After entering the blue medical tent in ...

The San Francisco 49ers enter Week 13 in pursuit of a win to snap their current two-game losing streak and for a win that can help ignite them during the season’s stretch run.