The Seattle Seahawks and San Francisco 49ers are the first teams in NFL history to meeting in a regular-season finale carrying six-game winning streaks.

The San Francisco 49ers had legendary wide receiver Jerry Rice back on the field ahead of Saturday's regular season finale against the Seattle Seahawks.

It all comes down to Week 18 in the NFC West and though the division title will come down to the Seahawks vs. 49ers matchup Saturday, the Rams aren't to be forgotten despite their Monday Night Football loss.

Before discussing how the 49ers match up against the parade of flawed teams they may face along the way, I’m going to explain how, to the surprise of even the most optimistic Niners watchers, the team is surviving the Fred Warner and Nick Bosa injuries on defense — and why that unit has real upside to be better in January.

The San Francisco 49ers have +800 odds to win the Super Bowl, fourth-best in the league as of Jan. 1.

On Saturday, the Carolina Panthers and Tampa Bay Buccaneers will battle for a spot in the playoffs, followed by the Seattle Seahawks and San Francisco 49ers facing off for the NFC West and the No. 1 seed in the conference.

There's just one full 16-game slate left in the 2025 NFL regular season, and some playoff spots -- and seeding -- are on the line. Both the AFC North and NFC So

Super Bowl LX will take place at Levi's Stadium in Santa Clara, California — home of the San Francisco 49ers — on Feb. 8, 2026. Here are the odds for the NFL title game at DraftKings Sportsbook as of Dec. 30, as the contenders and pretenders continue to emerge.

Week 18 is the league’s true rivalry slate, with 16 divisional duels to round out the campaign. Sunday night eliminates 18 teams into the long winter, while 14 playoff entrants formally begin their Super Bowl quests.