San Francisco will be without two of their biggest stars again, but should have their talented passer back in the saddle.

Heavy, lake-effect snow will fall on Buffalo this weekend as the 49ers arrive to face the Bills on Sunday night in the suburb ...

Purdy missed the 49ers' Week 12 contest versus the Green Bay Packers last Sunday with a right shoulder injury—a game San ...

The San Francisco 49ers have released their final injury report ahead of their Week 13 bout with the Buffalo Bills.

Running back Christian McCaffrey says the San Francisco 49ers are "hungry" to make a playoff push even with the defending NFC ...

San Francisco 49ers head coach Kyle Shanahan spoke with reporters after Friday's practice as the team prepares for its Week ...

Head coach Kyle Shanahan shared the final injury report on QB Brock Purdy, DL Nick Bosa and others and discussed the team's ...

The San Francisco 49ers are encouraged by linebacker Dre Greenlaw's progress as he works his way back from a torn Achilles ...

Kyle Shanahan takes a pragmatic approach to handling online criticism—he ignores it. The San Francisco 49ers head coach ...

San Francisco 49ers head coach Kyle Shanahan was strong in defending Christian McCaffrey from criticism following his poor ...

The Bills’ defense has plenty of experience against 21 personnel because Miami runs it the second most of any team in the NFL ...

San Francisco 49ers QB Brock Purdy shared his journey through injury recovery and looked ahead to the team's Week 13 matchup ...