San Francisco 49ers running back Christian McCaffrey (knee) suffered a PCL injury just four games into his return from the ...

It’s been an arduous year for Christian McCaffrey. A lingering Achilles injury cost him the first nine weeks of the season. Now, after just four games, he’s back on the shelf. What injury is McCaffrey ...

San Francisco 49ers head coach Kyle Shanahan addressed reporters during a Monday conference call, a day after the team's dominant 38-13 victory over the Chicago Bears. He shared several injury updates ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

San Francisco 49ers head coach Kyle Shanahan reaffirmed his commitment to the organization after a 38-13 win over the Chicago Bears on Sunday. "I don't ...

San Francisco 49ers cornerback Deommodore Lenoir is set to return for Sunday's game against the Chicago Bears after missing ...

The San Francisco 49ers have been dealing with all sorts of injury concerns in their offensive backfield. Star running back ...

San Francisco 49ers rookie running back Isaac Guerendo sustained a foot injury and is questionable to return in Sunday's ...

The 49ers have lost both of their top running backs to injuries. So how who will replace Christian McCaffrey and Jordan Mason ...

It's the final week of byes and also the swan song for the regular season in some fantasy leagues, making for an intriguing ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve and is likely out for the season after suffering a PCL injury in Week 13 agai ...