Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy by harnessing the body's immune system to target ...

The research represents a major step forward in revealing how the three dimensional form of DNA shapes the way human biology functions. In a major step toward understanding how the physical form of ...

These sequences are extremely prone to mutations and rank among the most functionally important regions in the entire human ...

Triglia discusses her research at the intersection of genetics, epigenetics, single-cell genomics and computational biology.

Humans have it. So does Drosophila. But not yeast. That "it" is a small pause at the start of gene activity - a brief molecular halt that may have ...

A newly revealed molecular tug-of-war may have implications for better understanding how a multitude of diseases and ...

Penn State researchers discovered that two proteins within the CCR4-NOT complex have opposing effects on mRNA stability.

A newly revealed molecular tug-of-war may have implications for better understanding how a multitude of diseases and ...

Analyzing stochastic cell-to-cell variability can potentially reveal causal interactions in gene regulatory networks.

A newly discovered promoter element "start" points to a shared regulatory syntax for controlling transcription initiation in ...

Angiopoietin-like protein 3 (ANGPTL3) inhibits lipoprotein and endothelial lipases. ANGPTL3 loss-of-function genetic variants are associated with decreased levels of low-density lipoprotein ...