A high-yield, one-pot, scalable reaction facilitates the production of biologically relevant amide compounds using less reactive nitrogen-containing heterocyclic compounds and carboxylic acid without ...

In proteins, amino acids are held together by amide bonds. These bonds are long-lived and are robust against changes in temperature, acidity, or alkalinity. Certain medicines make use of reactions ...

Linking molecular components through amide bonds is one of the most important reactions in research and the chemical industry. Scientists have now introduced a new type of reaction for making amide ...

A pair of copper catalysts can create chiral amides in a new, light-driven process, offering a useful alternative to the standard method for making these staples of medicinal chemistry (Nature 2021, ...

Even though amide bonds are everywhere—they hold proteins together and are essential components in many drugs—forging this molecular motif in a reaction flask can be challenging. For example, making ...

A catalyst that effectively converts amides to amines at low temperature under low hydrogen pressure has been demonstrated by a team of researchers. Amines are vital in nature; for example, amino ...