San Francisco 49ers quarterback Brock Purdy is poised to return to action on Sunday night against the Buffalo Bills after ...

The NFL is just about as unpredictable as the Buffalo weather at this time of the year, so the 49ers will take their ...

The San Francisco 49ers announced Friday that they have waived wide receiver Ronnie Bell ahead of their Sunday night game ...

The San Francisco 49ers are preparing for their Week 13 contest against the Buffalo Bills on Sunday at Highmark Stadium in ...

The San Francisco 49ers are preparing for their Week 13 contest against the Buffalo Bills on Sunday at Highmark Stadium in ...

San Francisco 49ers general manager John Lynch appeared on Bay Area radio station KNBR on Friday morning to share the latest ...

Heavy, lake-effect snow will fall on Buffalo this weekend as the 49ers arrive to face the Bills on Sunday night in the suburb ...

The San Francisco 49ers are encouraged by linebacker Dre Greenlaw's progress as he works his way back from a torn Achilles ...

The San Francisco 49ers announced Friday that they have waived wide receiver Ronnie Bell ahead of their Sunday night game ...

Brock Purdy is expected to return Sunday night against the Bills, but offensive tackle Trent Williams, defensive end Nick ...

The 49ers are set to have quarterback Brock Purdy back in the lineup this weekend. Purdy missed last Sunday's loss to the ...

San Francisco 49ers head coach Kyle Shanahan spoke with reporters after Friday's practice as the team prepares for its Week ...