Tumour suppressors of the Forkhead box O (FoxO) family are proposed to limit tumour growth through direct transcriptional regulation. Cytosolic FoxO1 can also suppress tumour growth by triggering ...
A protein that normally fosters tissue repair instead acts to inhibit healing when sugar levels are high. The role reversal helps explain why wounds heal slowly in people with diabetes. A protein that ...
The human vascular system, a complex network of blood vessels, plays an essential role in maintaining health. Understanding the molecular mechanisms underlying vascular development is important for ...
These days, lymphomas, leukemias, and other kinds of cancers can be effectively treated using chimeric antigen receptor T cell (CAR T) therapies. Now, new research from scientists at Children’s ...
The human vascular system, a complex network of blood vessels, plays an essential role in maintaining health. Understanding the molecular mechanisms underlying vascular development is important for ...
Results suggest FOXO1 controls SOX2 and OCT4 expression. Scientists claim the forkhead box O (FOXO) transcription factor FOXO1 is an essential component of the cellular control mechanism that ...
Characterizing PD-L1/PD-1 expression in hepatocellular carcinoma and implications on postresection treatment response. The efficacy and safety of lenvatinib in patients who did not meet the inclusion ...
A recent study revealed that the FOXO1 gene may play an important role in the pathological mechanisms of Parkinson's disease. A recent study led by researchers at Boston University School of Medicine ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 48 (December 1, 2020), pp. 30488-30497 (10 pages) Transforming growth factor-β (TGF-β) signaling is a ...
CancerScreen: A novel ultrasensitive liquid biopsy for early-stage cancer detection by ctDNA Duplex Sequencing and Tissue of Origin identification with supervised machine learning. This is an ASCO ...
Type 2 diabetes results from a combination of insulin resistance and dysfunction of insulin-producing pancreatic beta cells. Insulin deficiency is thought to be caused by both beta-cell dysfunction ...
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