FIC1 disease collectively refers to a group of autosomal-recessive familial liver disorders characterized by intrahepatic cholestasis due to mutations in the ATP8B1 gene (initially named FIC1).

Cholestatic liver diseases (CLDs) are a group of disorders characterized by the impairment of bile formation, secretion, or excretion. This impairment leads to bile acid accumulation in the liver, ...

Chronic cholestasis, defined as the impairment of bile acid formation and/or flow persisting for more than six months, encompasses a broad spectrum of hepatobiliary disorders, both heritable and ...

Age, female gender and obesity are well-known risk factors for cholesterol gallstone disease, which has an incidence of up to 15% in the Western world. The association between gallstones and obesity ...

The gall bladder is seldom brought up in conversation until it is out of order. This little, pear-shaped organ lies just under the liver and is the ma.

Cholesterol gallstone disease is characterized by several events, including cholesterol precipitation in bile, increased bile salt hydrophobicity and gallbladder inflammation. Here, we describe the ...

What are bile ducts? The bile ducts are small, tubular structures that play an important role in digestion by transporting bile -- a yellowish-green fluid -- from the liver and gallbladder to the ...

A bile duct obstruction is when one of the ducts that carry bile from the liver to the intestine becomes blocked. Symptoms may include nausea and vomiting, loss of appetite, and abdominal pain. This ...

Common symptoms are changes in stool appearance and texture. Normally, stool is brown, but people with bile duct cancer may have pale or clay-colored stools that are oily and float in water. Also ...

A bile duct drain, also called biliary drainage, can help treat blocked bile ducts so that bile may flow as it should, helping your liver digest fats. Learn more about biliary drainage, including how ...

When there’s a hole in any part of the bile duct, it can leak bile. This can occur during some procedures or due to injury. A bile duct is a tube-like structure that connects through your liver, ...