Oman and Qatar were leading efforts to begin ceasefire talks, while mediators said Iran was open to resuming nuclear negotiations if Israel’s attacks stop.

Iran has arrested dozens of people on suspicion of spying as fears grow in the Islamic Republic over the extent of its infiltration by Israel’s Mossad intelligence service.

Blasts rang out across a swath of the Middle Eastern republic’s territory, targeting its nuclear capabilities, military leadership and scientists.

The head of the International Atomic Energy Agency says there is a possibility of both radiological and chemical contamination within Iran’s main nuclear enrichment facility in Natanz.

Since Israel began its concerted attack on Iran on Friday, calls for regime change in Iran have grown louder – from hawks in the US Congress to Israeli officials and some Iranian activists abroad.

President Trump rejected an Israeli plan in recent days to kill Iran's Supreme Leader Ayatollah Ali Khamenei, a senior U.S. official told USA TODAY.

Investors are regaining some appetite for risk amid rising optimism that the conflict won't spill over into a broader regional crisis.

Israel’s military said it hit command centers of Iran’s Revolutionary Guard, while Iranian strikes overnight killed several people.