Acyclic nucleoside phosphonates (ANPs) represent a vital class of compounds with significant applications in antiviral and antiparasitic therapy. Characterised by a non-hydrolyzable phosphonate group, ...
Northwestern Medicine scientists have uncovered a surprising link between a tiny cellular engine and the way cancer cells build the DNA they need to proliferate, according to a new study published in ...
When treated with KRAS inhibitors alone, cancer cells can escape destruction by using the salvage pathway to gather additional nucleosides to repair the DNA damage. Combining TRE-515 with KRAS ...
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