Enzymes have long captivated biologists and chemists by performing difficult reactions rapidly and selectively in aqueous environments. The designs of enzymes catalyzing a retro-aldol reaction and a ...

IN A DRAMATIC EXAMPLE of translation from in silico to in vitro, scientists have computationally designed a series of new enzymes that catalyze a multistep reaction-including the breaking of a ...

Chemists from UCLA and the University of Washington have succeeded in creating "designer enzymes," a major milestone in computational chemistry and protein engineering. The research, by a UCLA ...

Three hallmarks of life are that it can replicate, metabolize molecules to build and power itself, and compartmentalize these different reactions. Sijbren Otto and coworkers at the University of ...

The Thermo Scientific picoSpin 45 NMR spectrometer is a useful tool for teaching through the aldol condensation reaction. In a number of undergraduate organic teaching programs, probably the first ...

In March, David Baker at the University of Washington in Seattle and his colleagues reported the rational design of enzymes for reactions that have no known catalysts. The team took advantage of the ...