Haemoglobin is a paradigm for exploring allosteric regulation, wherein ligand binding at one site induces conformational changes that affect functional activity at a distant site. These structural ...

The pathology of sickle cell disease is caused by polymerization of the abnormal hemoglobin S upon deoxygenation in the tissues to form fibers in red cells, causing them to deform and occlude the ...

Sickle cell disease (SCD) is a genetic disorder that causes red blood cells to take the shape of a sickle or a letter “C.” Levels of hemoglobin, a protein that helps carry oxygen on red blood cells, ...