Saol Therapeutics, a privately held clinical-stage pharmaceutical company, today announced that the company has been granted ...

Saol Therapeutics received a complete response letter for its pyruvate dehydrogenase complex deficiency treatment a week ...

Glucose is not only a major nutrient regulator of insulin secretion, but also impacts on gene expression in beta-cells. Using a mouse model of beta-cell-specific knock-out of Pdha1 gene which encodes ...

Lung cancer, notorious for its high mortality rates, is a leading cause of cancer-related deaths globally, with metastasis being the primary contributor to poor patient outcomes. A critical factor in ...

ROSWELL, Ga. and DUBLIN and HAMILTON, Bermuda, Oct. 4, 2022 /PRNewswire/ -- Saol Therapeutics, a privately held, clinical-stage pharmaceutical company, announced today that the pivotal Phase 3 ...

This is a preview. Log in through your library . Abstract The requirements for reactivation (dephosphorylation) of the pea (Pisum sativum L.) leaf mitochondrial pyruvate dehydrogenase complex (PDC) ...

The mitochondrial pyruvate dehydrogenase complex (mtPDC) plays a pivotal role in controlling the entry of carbon into the tricarboxylic acid (TCA) cycle for energy production. This multi-enzyme ...

The pyruvate dehydrogenase complex consists of many different enzymes (marked in different colours). Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to ...

A new method has enabled the natural structure of particularly large and complex enzymes to be revealed. Scientists at Martin Luther University Halle-Wittenberg (MLU) and TU Berlin have published ...