Human development starts from the fertilization of a fully matured oocyte. Oocyte maturation, fertilization, and early embryo development before zygotic activation is characterized by the absence of ...

As their name suggests, messenger RNAs (mRNAs) act as intermediary molecules in the transfer of genetic information from DNA to their translation into proteins. In eukaryotic organisms, including ...

Writing in Molecular Therapy Nucleic Acids, researchers hypothesized that using poly(A) tail mimetics to enhance mRNA expression from haploinsufficiency-associated genes could be a disease-modifying ...

Advances in mRNA design continue to shape the next generation of therapeutic development. Yet, achieving strong and sustained protein expression remains a persistent challenge across platforms.

Cells regulate RNA and protein abundance through a multi-layered process. Excitingly, peeling back one layer has revealed additional layers below, highlighting the complex nature of this process. For ...

mRNA-based therapies catapulted to the forefront of public consciousness in the form of vaccines against the SARS-CoV-2 virus. After that success, mRNA therapeutics are now being developed for an ever ...

For such a system to operate efficiently, poly (A) tails must have a precise length when they enter the cytoplasm and, consequently, when they are made in the nucleus. Indeed, this is the case, with ...