The onset and aggressiveness of cancer are related to the abnormal behavior of certain genes, known as oncogenes. The best-known of these alterations is mutation, but it is not the only one. Sometimes ...
A team from CNIO and CIEMAT eliminates cells that contain excessive copies of oncogenes using CRISPR gene editing. In cellular and animal models of neuroblastoma, small cell lung cancer and colon ...
In certain cancers, oncogene amplification is correlated with an immunologically cold or noninflamed, tumor immune microenvironment (TIME) and a worse prognosis, for example, in the case of ...
How does a proto-oncogene cause cancer? In the early twentieth century, a tumor-causing virus called the Rous sarcoma virus (retrovirus) was discovered. 3 Host cell proto-oncogene (c-src) and Rous ...
Breast cancers at all stages are defined by the structure of their genomes, researchers find. Targeting these processes early is likely to offer unexpected therapeutic avenues. Breast cancers can be ...
Researchers at the University of California at San Francisco have identified an RNA-binding protein that increased the translation of Myc mRNA. The authors wrote that their work, which was published ...
About 30,000 cases of lung cancer occur in Spain each year. Mutations in KRAS oncogenes account for 10-15% of these cases, a subgroup against which there are still no effective therapies. Researchers ...
Initiating targeted therapy for eligible patients with advanced non–small cell lung cancer (NSCLC) was found to improve outcomes, even when patients were started on nontargeted therapy but switched in ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results