Researchers at Kanazawa University report in Cell Reports how alterations in the nuclear pores lead to the degradation of anti-tumor proteins. Several types of cancer are believed to be linked to ...

New mechanism determined for passive transport of biomolecules through the nuclear pore complex of cells. Research can help guide the development of future therapeutics for human diseases such as ...

The nuclear pore complex (NPC) is an essential, highly dynamic macromolecular assembly embedded in the nuclear envelope that orchestrates the precise exchange of proteins, RNA and other macromolecules ...

If the human cell is a nightclub, then the nucleus is a VIP lounge and the nuclear pore complex is the bouncer Beckman Institute for Advanced Science and Technology If the human cell is a nightclub, ...

“With the high-speed AFM we could, for the first time, peer inside native nuclear pore complexes only forty nanometers in size,” study coauthor Roderick Lim of the University of Basel said in a ...

If the cell nucleus is like a bank for DNA, nuclear pores are the security doors around its perimeter. Yet more security doors aren't necessarily better: some cancer cells contain a dramatic excess of ...

Just as cities must carefully manage the flow of cars in and out of downtown, cells regulate the movement of molecules into and out of the nucleus. This microscopic metropolis relies on an intricate ...

Dynamic network in the pores of the nuclear envelope blocks dangerous invaders. Tiny pores in the cell nucleus play an essential role for healthy aging by protecting and preserving the genetic ...

The human NPC is composed of approximately 34 nucleoporin proteins. The interior, or “symmetric,” core is composed of an inner ring, and two outer rings that sit on either side of the nuclear envelope ...