Tumor cell deaths can benefit tumors. A paradox? Not at all. If, for example, a dying tumor cell undergoes necroptosis, it can release inflammatory factors that can enhance or diminish antitumor ...

Researchers have identified a previously unknown inflammatory mechanism that may drive the aggressiveness and relapse of small cell lung cancer. Small cell lung cancer (SCLC) is among the most ...

When they find themselves trapped in an amyloid-ridden mouse brain, transplanted human neurons meet an untimely, necrotic demise. While this had been known before, a new-and-improved xenograft model ...

A new study reveals the dual role of MLKL in necroptosis, paving the way for new treatments for inflammatory diseases In multicellular organisms, damaged cells are systematically removed to maintain ...

Necroptosis is a form of programmed cell death, distinguished by rupturing of the cell membrane, swelling of the organelles, and spillage of internal cellular components. This form of cell death ...

Scientists at UT Southwestern in Dallas say they have finally nailed down the human protein that makes cells literally burst during necroptosis, a form of inflammatory programmed cell death. The work ...

The term ‘necroptosis’ is used to describe a form of cell death that is not blocked by caspase inhibitors or by overexpression of anti-apoptotic Bcl-2 family members. Typically, necroptosis has been ...

Small cell lung cancer (SCLC) is one of the most aggressive forms of lung cancer, with a five-year survival rate of only 5%. Despite this poor prognosis, SCLC is initially highly responsive to ...

Image-guided vacuum-assisted biopsy to assess pathologic complete response in breast cancer patients with exceptional response to neoadjuvant chemotherapy. This is an ASCO Meeting Abstract from the ...

The aim of immunotherapy strategies is to leverage cells in the patient's own immune system to destroy tumor cells. Using a preclinical model, scientists from the Institut Pasteur and Inserm ...

A team of researchers at the University of Cologne's Center for Biochemistry, together with the Bambino Gesù Pediatric Hospital in Rome, Italy, have discovered a fundamental biological mechanism that ...