The Buffalo Bills will look to lock up a playoff spot in their Week 13 showdown with the San Francisco 49ers. Here are five storylines to watch.

A light dusting of snow began covering the Buffalo Bills' facility on Friday as the team completed its final practice of the week inside Highmark Stadium.

San Francisco 49ers quarterback Brock Purdy is poised to return to action on Sunday night against the Buffalo Bills after missing a game due to a shoulder injury.

Colin Cowherd believes that the Buffalo Bills are the best team in the NFL when playing at full strength. Somebody forgot to tell members of the Buffalo Bills’ locker room that 2024 was supposed to be a rebuilding year.

You can listen on SiriusXM satellite radio on channel 225 (Bills feed) and channel 226 (49ers feed), and on traditional radio, the Bills Radio Network has stations all across the state. Chris Brown has the play-by-play, Eric Wood is the analyst, and Sal Capaccio is the sideline reporter. The network includes:

After its Week 11 party in Buffalo, "The NFL Today" crew is hitting the road again. This time, the NFL on CBS pregame show will broadcast live from Ford Field in anticipation of the Detroit Lions' Week 15 matchup against Josh Allen and the Buffalo Bills.

Running back Christian McCaffrey says the San Francisco 49ers are "hungry" to make a playoff push even with the defending NFC champions sitting at 5-6.

San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got destroyed by the Green Bay Packers. Granted Brock Purdy didn't play, but the 49ers didn't look like an NFC contender.

Three teams face playoff-clinching scenarios in Week 13. Here's what the Bills, Lions and Chiefs need to earn a playoff berth.

Kansas City Chiefs quarterback Patrick Mahomes has been fined more than $14,000 for pantomiming what the NFL deemed a "violent gesture" during a game last week against the Buffalo Bills.

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco 49ers and Buffalo Bills.