Polymerase chain reaction with allele-specific oligonucleotides (ASO-PCR) is a technique that can discriminate low levels of the mutant sequence against a background high in wild-type DNA. 14 In ...

The adaptor protein MyD88 is involved in interleukin 1 receptor and Toll-like receptor signaling. Unexpectedly, new evidence shows that MyD88 also participates in interferon-γ-induced cellular ...

In a recent study published in the Journal of Experimental Medicine, researchers identified that individuals with a deficiency of myeloid differentiation primary response 88 (MyD88) and interleukin-1 ...

Brukinsa achieved higher complete or very good partial response rates than Imbruvica in MYD88-mutated Waldenström macroglobulinemia patients. Brukinsa demonstrated faster response times and more ...

Does stage migration exist in active multiple myeloma (MM)? This is an ASCO Meeting Abstract from the 2012 ASCO Annual Meeting I. This abstract does not include a full text component.

We performed a prospective study of ibrutinib in 63 symptomatic patients with Waldenström’s macroglobulinemia who had received at least one previous treatment, and we investigated the effect of MYD88 ...

Samira Kiani is a co-founder and founding CSO of Safegen Therapeutics. She receives funding from National Institute of Health for her research program. One of the major challenges facing gene therapy ...