The hunt for antivirals has reached an unprecedented pace in light of the coronavirus 2019 (COVID-19) pandemic. The causal agent for this disease – severe acute respiratory syndrome coronavirus 2 ...

For the majority of Duchenne muscular dystrophy (DMD) mutations, antisense oligonucleotide (AON)-mediated exon skipping has the potential to restore a functional protein. Here we show that weekly ...

Transfection methods for gene regulation were widely investigated after the discovery of RNAi. 16 The DNA nanotechnology concept has shown promising results for the transfection of siRNA and antisense ...

At the IDWeek 2023 infectious disease conference, Rachelle Koch, a medical student from the University of Texas Southwestern Medical Center, presented the work done in David Greenberg’s Lab on a new ...

A morpholino is a synthetic oligomer molecule that contains DNA bases on a methylene morpholine backbone, hence the naming convention: morpholine oligomer. Image Credit: Phonlamai ...

In vivo morpholino oligomers targeting the 3′ untranslated region show efficacy against dengue virus Jan. 3, 2025 ...

Indiana University School of Medicine scientists have developed a new method that shifts the behavior of immunosuppressive cells in tumors, turning them from cancer protectors into tumor fighters.