The JAK2 gene is a protein-coding gene of the Janus kinase family. It plays a role in cellular signaling. Evidence notes connections between this gene and some medical conditions. Variations in this ...
Figure 1: JAK2 is present in the nucleus of haematopoietic cells. Figure 3: HP1α binds the Y41 region of H3 in a phosphorylation-dependent manner. Figure 4: JAK2 signalling regulates the expression of ...
A new report found only about 2.8% of people with myelodysplastic syndromes (MDS) have JAK2 mutations. A new report is shining a light on an uncommon—but potentially meaningful—characteristic of some ...
Development of potent JAK2 inhibitors for MPN treatment needs to satisfy several criteria. First, they must be specific to JAKs over other kinases to avoid any off-target toxicity. Drug exploitation ...
Picomolar potency and > 500-fold selectivity for JAK2 V617F JH2 versus WT JAK2 JH2 in cellular assays. 100× selective inhibition of pSTAT5 phosphorylation and proliferation in BaF3 JAK2 V617F and ...
The JAK2 enzyme has long been associated with myelofibrosis (MF). The newest and most promising treatments stop or slow down the enzyme, which may help slow down the disease. Nick David/Getty Images ...
ZRSR2 mutations are linked to JAK2 V617R-driven MPNs but are insufficient alone for disease progression. CRISPR-Cas9 studies showed ZRSR2 loss causes intron retention and transcriptional changes ...
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What Is a JAK2 Mutation?
A JAK2 mutation is a change in the gene that can cause uncontrolled blood cell production. JAK2 mutations are linked to blood cancers and disorders like polycythemia vera and essential thrombocythemia ...
QIAGEN announced that it has received clearance for its ipsogen JAK2 RGQ PCR Kit (ipsogen JAK2 assay) from the U.S. Food and Drug Administration (FDA) for additional use in the diagnosis of all ...
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