Insulin is one of the most potent and pleiotropic hormones in the body, regulating a myriad of physiological processes. However, perhaps none is best studied as its role in regulating glucose ...

The insulin receptor (IR) is a prototypical receptor tyrosine kinase that orchestrates critical cellular processes, including metabolism, cell growth and differentiation. Activation of the IR involves ...

Glycine, a non-essential amino acid derived from serine, plays an increasingly recognized role in metabolic regulation.

Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study by a team at the Max Planck Institute ...

Obesity has become a global epidemic affecting diverse populations and leading to metabolic syndrome across different sexes and age groups. A significant aspect of obesity is the development of leptin ...

Three years ago, the inceptor protein was discovered and its role as an inhibitor of the insulin signaling pathway was described. Inceptor and the insulin receptor are located on the surface of beta ...

How does obesity affect insulin production? Researchers are shining light on new stages of the ERK pathway. Researchers at the Tohoku University Graduate School of Medicine have uncovered a key ...

Glucose imbalance develops gradually through everyday eating habits that often feel harmless in isolation. Globally, about ...

Eating less may rewire aging muscles in surprisingly different ways for males and females. A new study shows that cutting calorie intake triggers sweeping changes in the proteins of rat skeletal ...

The 8-Bromo-cAMP sodium salt PKA activator, a synthetic analog of cAMP, is one of the most potent tools of investigating and playing with this pathway, which has become an essential part of ...

Elevated fasting blood sugar and insulin levels, along with reduced insulin sensitivity, may predict cognitive impairment in MS patients. The study found significant correlations between cognitive ...