Following the Structural Genomics Initiative to solve as many unique protein structures as possible; the Protein Data Bank contains several enzymes whose structures have been solved, but for which no ...
Breast cancer is a highly heterogeneous disease, with many subtypes showing distinct pathological features and clinical outcomes. Among different subtypes, luminal breast cancer accounts for more than ...
Respiratory infections can be severe, even deadly, in some individuals, but not in others. Scientists have gained new understanding of why this is the case by uncovering an early molecular driver that ...
T. Pacuszka and P. H. Fishman, J. Biol. Chem., 265, 7673 (1990). M. L. Philips, E, Nudelman, F. C. A. Gaeta, M. Perez, A. K. Singhal, S. Hakomori, and J. C. Paulson ...
While protein design is experiencing a period of rapid development and advancement, there’s one particularly challenging class of proteins that’s giving researchers a hard time: enzymes. Now ...
New research represents a notable step forward in designing enzymes from scratch. With their approach, the authors designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, ...
When peatlands and permafrost lose moisture, huge amounts of carbon sequestered there can oxidize and return to the atmosphere as carbon dioxide, a greenhouse gas (SN: 12/16/00, p. 396). Now, ...
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