The mechanism of action and resistance of sunitinib in RCC. Background: NF2 inactivation is one of the major genetic alterations in MPM and has recently been causally associated with activation of the ...

Establishing a neoadjuvant platform for developing targeted agents: Degarelix prior to prostatectomy for patients with intermediate- and high-risk prostate cancer. A phase I/II study of the ...

Enzymes are biological catalysts that speed up chemical reactions in living organisms. They are essential for life, as they play a crucial role in various biological processes, such as digestion, ...

Antimicrobial design; targeted protein degradation; mTORC1 inhibition; enzyme structure-function studies. My laboratory uses approaches derived from both chemistry and biology. Projects include ...

The results of a preclinical study by lymphoma researchers at Weill Cornell Medicine suggest that an emerging class of anticancer drugs called EZH2 inhibitors may greatly enhance the potency of some ...

An international study led by scientists at Flinders University and at South China University of Technology has uncovered a new vulnerability in prostate cancer cells that could help improve treatment ...