Transverse tubules (T-tubules) play a significant role in muscle contraction. However, the underlying mechanism of their ...

Proteins that are no longer needed, defective, or potentially harmful are labeled with a molecular "tag" and dismantled in ...

Novel E3 ligase identified by Kymera’s Whole-Body Atlas is expressed in selected tissues while broadly expressed in cancer cells Novel STAT3 degrader enabled by Pegasus TM platform, and based on ...

Three years after launching from the lab of University of California, San Francisco chemist Jim Wells, the start-up EpiBiologics has raised $109 million in series B funding to propel its ...

In eukaryotes, ubiquitination is an important posttranslational process achieved through a cascade of ubiquitin-activating (E1), conjugating (E2), and ligase (E3) enzymes. Many pathogenic bacteria ...

This article and associated images are based on a poster originally authored by Ashleigh Hill, Marie-Louise Francis, Viktoria Brachmaier, Egle Vaitone, Rachel Forfar and Sandra Kuemper and presented ...

Ethylene influences plant growth, development, and stress responses via crosstalk with other phytohormones; however, the underlying molecular mechanisms are still unclear. Here, we describe a ...

An illustration of Lynn McGregor. Credit: Courtesy of Lynn McGregor (McGregor); Novartis (E3 ligase); RCSB PDB (KRAS); Courtesy of Colin Garvie (protein gels) If I weren’t a chemist, I’d be: A ...

Targeted protein degradation (TPD) has transformed cancer drug discovery by enabling removal of harmful proteins using small molecule degraders. PROTACs (Proteolysis Targeting Chimeras) and MGDs ...