Blocking USP15 results in smaller tumors in mice with human cancer. Scientists have identified ubiquitin-specific peptidase 15 (USP15) as a key regulator of the cancer-promoting transforming growth ...

This is a preview. Log in through your library . Abstract The reversibility of ubiquitination by the action of deubiquitinating enzymes (DUBs) serves as an important regulatory layer within the ...

Fubi is produced by cells as a fusion protein with the ribosomal protein S30, and must be separated from S30 by proteases for functioning ribosomes. In immune cells, this by-product of ribosome ...

This is a preview. Log in through your library . Abstract Endoplasmic reticulum (ER) stress plays an important role in metabolic diseases like obesity and type 2 diabetes mellitus (T2DM), although the ...

Researchers at Pennington Biomedical Research Center have revealed critical insights into how impaired mitochondrial dynamics and quality control mechanisms in skeletal muscle influence insulin ...