PEGASUS generates permeable macrocyclic peptides, offering new promise for a modality that can combine the properties of a biologic in a pill ...

The nonapeptide Oxytocin is a cyclic nine-amino‐acid peptide that has long been studied for its possible roles in ...

It achieves AI-driven generative design of the first permeable macrocyclic peptide with more than two polar or ionizable fragments. -- Surrogate assays are a breakthrough for AI model training. 1910 ...

FUJIFILM Corporation announces the successful validation of the cancer cell-targeting potential of its peptide-oligonucleotide conjugates. This validation resulted from combining oligonucleotides with ...

Cyclic peptides often exhibit low membrane permeability which can be significantly improved via amide-to-ester substitutions—as demonstrated by researchers from Tokyo Institute of Technology (Tokyo ...

Cyclic peptides derived from flaxseed, commonly known as cyclolinopeptides or linusorbs, represent a unique class of naturally occurring bioactive compounds. Their cyclic structure confers enhanced ...

Orbis Medicines emerged from stealth Feb. 29 with $28 million in seed funding. The company is the latest launched to turn cyclic peptide molecules into orally available drugs that could replace ...

Scientists have developed stable orally available cyclic peptides with a much higher bioavailability than current ones, virtually creating a generation of drugs that can target previously untreatable ...

For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat ...

There has been a recent revival in interest in peptide therapeutic development, with five of the top-selling drugs being peptides or proteins (Enbrel, Remicade, Humira, Avastin, MabThera) and many ...

For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat ...