Aspirin was introduced into clinical medicine in 1899 and its anti-inflammatory, analgesic and antipyretic properties were accompanied by the onset of gastrointestinal and renal toxicity. Over the ...
Cyclooxygenase-2 (COX-2) inhibitors have long been employed to modulate inflammatory responses in a range of conditions, from arthritis to malignancies. In recent years, the convergence of ...
Taking the oral cyclo-oxygenase (COX)-2 inhibitor piroxicam in combination with levonorgestrel improved emergency contraception efficacy versus levonorgestrel alone, with no additional adverse events, ...
A drug developer's dream, rationally designed to quell inflammation, COX-2 inhibitors are also prime candidates for preventing cancer or its recurrence. Gary J. Kelloff, chief of the chemoprevention ...
A phase I-II trial of docetaxel and daily thalidomide in patients with previously treated recurrent non-small cell lung cancer No significant financial relationships to disclose. This is an ASCO ...
Augusta University has patented NSAID derivatives acting as prostaglandin G/H synthase 1 (PTGS1; COX-1) and/or COX-2 inhibitors potentially useful for the treatment of inflammation and pain.
Scientists have succeeded in reducing levels of the bovine leukemia virus (BLV) in cows with severe infections by combining an immune checkpoint inhibitor and an enzyme inhibitor. The finding could be ...
BAE: Bovine aortic endothelial; RHP: Recombinant human protein. NSAIDs variably inhibit prostaglandin H synthase (COX). COX-2 was cloned in 1991, and it was subsequently established that COX-1 does ...
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