The SportsLine Projection Model is high on the road team. It has the Colts covering the spread in 57% of simulations and winning outright in 34% to bring value as +455 underdogs. The model has the Over hitting in 65% of simulations.

Here are three things to know about the Indianapolis Colts vs. Houston Texans Week 18 game, plus a prediction.

Stroud finished his day against the Colts completing 14 of 23 passes for 169 yards and a touchdown, capping off his 2025 campaign with just over 3,000 yards passing, 19 touchdowns, and eight interceptions through the 15 games he appeared in.

Preview the Week 18 matchup between the Houston Texans and Indianapolis Colts with predictions, odds, over/under, spread, betting lines and more.

The Indianapolis Colts and the Houston Texans face off in Week 18 of the NFL regular season. Here's where to watch and start time.

The Houston Texans have rattled off nine straight wins to secure a 12-win season and a playoff bid following a victory over the Colts.

There were bright spots from the loss to the Houston Texans, but the Indianapolis Colts have a long offseason ahead.

Colts receiver Alec Pierce hit the 1,000-yard milestone but was ejected for making contact with official in the team's season finale loss to the Houston Texans on Sunday.