Set to face off for the 128th time in a matchup dubbed 'Big Game,' this game means more to the Cardinal than just playing against their Bay Area rivals. In fact, going into the season, this game was circled on the calendar as the most important game for the Cardinal.

The North Carolina Tar Heels (3-5) return home looking for a second Atlantic Coast Conference straight win as they host the Stanford Cardinal (3-6) at Kenan Stadium in Chapel Hill on Saturday night.

No. 17 USC recorded a statement win with a 26-21 victory over No. 21 Iowa at home. The Trojans held the Hawkeyes scoreless in the second half and erased an early 21-7 deficit to move to 8-2 (6-1 Big Ten). USC was powered by another big performance from star wide receiver Makai Lemon, who finished with 10 catches for 153 yards and a touchdown.

The Fighting Irish are led by first-year starting quarterback CJ Carr. He has thrown for 2,275 yards, 19 touchdowns and four interceptions. Pairing him with running back Jeremiyah Love, who has 988 rushing yards and 13 touchdowns, Notre Dame's offense has been productive.

Arizona Cardinals vs San Francisco 49ers picks, predictions, odds, win probabilities for NFL Week 11 Sunday game on Nov. 16. Who will win game today?

Notre Dame will be heavy favorites against Syracuse and Stanford to end the season, and would likely make the Playoff at 10-2.