Bile acid metabolism disorders encompass a range of rare, yet clinically significant, genetic conditions that disrupt the normal synthesis and regulation of bile acids by the liver. These conditions, ...

Liver is the major organ for metabolism of sulfur amino acids (methionine, cysteine, taurine) and expresses high levels of sulfur amino acid synthesis and metabolising enzymes. Dietary intake, ...

The integrated analysis of serum and fecal metabolites uncovers the significant disruption of bile acid metabolites as a key contributing factor in the pathogenesis of DILI. Our study offers promising ...

Drug-induced liver injury (DILI) is a significant concern in clinical practice, arising from medications, herbs, and dietary supplements. It can manifest in different forms, including hepatocellular, ...

Immunotherapy is a modern approach to cancer treatment that uses a patient's own immune system to help fight tumors. It has made an incredible impact on treating cancers in many different organ ...

Bile acids are essential to digestion, by acting like a kind of detergent that breaks up fat molecules. Fat doesn't dissolve in water, but our digestive system is full of water, so the fat we consume ...

A mysterious gut hormone may be behind many cases of chronic diarrhea, especially in people with undiagnosed bile acid malabsorption, a condition often mistaken for irritable bowel syndrome.

DEAR DR. ROACH: I’m a 67-year-old female in pretty good health. The only medications I take are for my thyroid, arthritis and hormone replacement. Early last year, I was sick with a cold/flu for a ...

The authors provide a useful integrated analytical approach to investigating MASLD focused on diverse multiomic integration methods. The strength of evidence for this new resource is solid, as ...

Immunotherapy is a modern approach to cancer treatment that uses a patient's own immune system to help fight tumors. It has made an incredible impact on treating cancers in many different organ ...