Alkyl radicals are carbon radicals of normal chain and branched chain alkanes, available as reaction intermediates even at late stages of synthesis. Recently, it has become possible to generate alkyl ...

Researchers have developed a new photo-uncaging system for photodynamic cancer therapy using organorhodium(III) phthalocyanine complexes that are activated in situ by pulsed light to release alkyl ...

Because ketones are widespread in organic molecules, chemists are eager to develop new reactions that use them to form chemical bonds. One challenging reaction is the one-electron reduction of ketones ...

A research team has developed a reaction for creating functionalized ketones. Using an N-heterocyclic carbene (NHC) organocatalyst, with no need for metals or light irradiation, an acyl and an alkyl ...

Making molecules with quaternary carbon bonds—four carbons attached to a central C—is tricky but necessary for medicinal chemists. Quaternary C bonds have a discrete shape, Princeton University ...

Researchers have developed a new photo-uncaging system for activating cancer-fighting agents at the site of the tumor. The system involves the use of organorhodium(III) phthalocyanine (Pc) complexes, ...

A pair of copper catalysts can create chiral amides in a new, light-driven process, offering a useful alternative to the standard method for making these staples of medicinal chemistry (Nature 2021, ...

One approach to treating cancer is photodynamic therapy using photo-uncaging systems, in which light is used to activate a cancer-fighting agent in situ at the tumor. However, suitable agents must be ...