Mac Jones' revitalized play presents the 49ers a compelling trade chip. ESPN highlights his potential to fetch valuable assets this offseason.

The San Francisco 49ers cannot just walk into Indianapolis and beat the Colts without putting in a good effort; their roster is too strong for that. However, this is a team that is falling apart and they have a few glaring issues that can be exposed by the right team.

It wasn't just the Seahawks celebrating Thursday's night win. The 49ers now have a path to the NFC West title, too.

It’s been a much different year for the 49ers, who have dealt with major injuries on both sides of the ball, including season-ending ones for Nick Bosa and Fred Warner. Still, they’re sitting at 10-4 with a chance to get the NFC’s No. 1 seed, should they win their final three games of the season.

The Indianapolis Colts have gone 1-5 in their last six games. Key players at impact positions are now out, and the team is sputtering to the finish line. They are significant underdogs to the San Francisco 49ers despite being at home on Monday Night Football in Week 16.

Find single game tickets to the San Francisco 49ers vs. Indianapolis Colts NFL Week 16 matchup on Monday, December 22, 2025 at Lucas Oil Stadium.

A lot of the 49ers' biggest contributors weren't on the team last year. Heck, some of them weren't even on the team in Week 1.

www.si.com/nfl/49ers/onsi These San Francisco 49ers should make the 2025 Pro Bowl Brian Walshe is set to be sentenced on Thursday after a Massachusetts jury found him guilty of killing and dismembering his wife, the mother of their three children.

Tight end George Kittle's wife has partnered with Smirnoff to continue bringing high spirits to the suite amid all the NFL madness

Niners bolster QB depth with Adrian Martinez's return and scout offensive line talent, preparing for playoff challenges and potential injuries.